The present work describes a novel, simple, and fast electroanalytical methodology for naproxen nap determination in pharmaceutical formulations and biological fluids in the presence of its degradation products. Pdf dysprosium nanowire modified carbon paste electrode. Naproxen and other nsaids are usually recommended to be discontinued for a time before surgery to prevent too much bleeding during the procedure. Preparation and study of a naproxen ionselective electrode. The electrochemical oxidation and determination of paracetamol were easily carried out on borndoped diamond bdd electrode using two voltammetric techniques cv and dpv. A novel potentiometric naproxenate ion sensor immobilized. Naproxen ionselective electrode and its application to pharmaceutical analysis article pdf available in acta poloniae pharmaceutica 593. Determination of naproxen is the main aim of this study. This modified electrode exhibited a potent and persistent electronmediating behavior followed by wellseparated oxidation peaks toward naproxen and paracetamol at a scan rate of 100 mvs1 with. Properties of naproxen ionselective electrodes request pdf. In this study, our main goal is to determine how incorporation of zinc oxide zno nanoparticles and multiwalled carbon nanotubes can change the performance of a carbon paste electrode in oxidation of naproxen. Electrochemistry and electrocatalysis of hemoglobin in.
Dec 01, 2008 abstract naproxen membrane electrodes based on different plasticizers and the quaternary ammonium salts qass dimethyldidecylammonium bromide, methyltrioctylammonium chloride, or tetraoctylammonium chloride, were prepared. Voltammetric determination of diclofenac sodium using. The potential difference, which is measured in volts v, depends upon the particular substances constituting the electrodes. Cyclic voltammetry was used to study the influence of ph on the anodic peak current of dcf.
Naproxen is contraindicated in the setting of coronary artery bypass graft surgery cabg. These reactions involve electric charges moving between electrodes and an electrolyte or ionic species in a solution. Cv notes naproxen naproxen is a potent nonsteroidal antiinflammatory, analgesic, and antipyretic drug in widespread clinical use for rheumatism and osteoarthritis. Electroanalytical investigation on paracetamol on boron. Each solution was stirred and the potential reading was recorded at equilibrium. Pdf naproxen ionselective electrode and its application. It is available in immediate and delayed release formulations.
Voltammetric analysis of naproxen in graphite electrodes and. Naproxen electrochemical degradation by cyclic voltammetry was already studied by chin et al. The electrooxidation of naproxen was studied, for the first time, using boron. For any electric cell, the total potential is the sum of those produced by the reactions at the two electrodes. Naproxen membrane electrodes based on different plasticizers and the quaternary ammonium salts qass dimethyldidecylammonium bromide, methyltrioctylammonium chloride, or tetraoctylammonium chloride, were prepared.
Electrochemical degradation of naproxen from water by. Room temperature ionic liquid nbutylpyridinium hexafluorophosphate bppf6 was used as a binder to construct a new carbon ionic liquid electrode cile, which exhibited enhanced electrochemical behavior as compared with the traditional carbon paste electrode with paraffin. Voltammetric analysis of naproxen in graphite electrodes. Tmj and tens unit where to place electrode pads on your. The calibration curves obtained by plotting the response against the naproxen concentration logarithmic functions.
Naprelan naproxen sodium is a nonsteroidal antiinflammatory drug used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis and acute gout. Experimental reagents rnaproxen and snaproxen purity. Read determination of naproxen in pharmaceuticals by differential pulse voltammetry at a platinum electrode, analytica chimica acta on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The electrode was applied for determination of naproxen in drugs. An electroanalytical method was developed for the direct quantitative determination of paracetamol in tablets based on its oxidation behavior. The proposed sensor displayed good selectivity for naproxen in the presence of several substances, especially concerning carboxylate and inorganic anions. An anodic current maximum was recorded at a potential of. Effects of electrode reversal on the distribution of naproxen. Electrochemistry is the branch of physical chemistry that studies the relationship between electricity, as a measurable and quantitative phenomenon, and identifiable chemical change, with either electricity considered an outcome of a particular chemical change or vice versa. Potentiometric determination of ibuprofen, indomethacin and. Simultaneous electrochemical quantification of naproxen. Naproxen may also be used for purposes not listed in this medication guide. The chiral recognition was based on different interactions of s and rnap enantiomers with the chiral surface of the constructed enantioselective electrode. Introduction you have already studied oxidationreduction reactions in the previous laboratory experiment.
The nanogel was synthesized by insitu free radical polymerization. Microsoft powerpoint electrode placementegv2 readonly compatibility mode. Aug 28, 2019 the nanogel was synthesized by insitu free radical polymerization. It is shown, for the first time, that a bare carbon paste electrode can be used for the simultaneous quantification of antiinflammatory drugs. Important information you should not use naproxen if you have a history of allergic reaction to aspirin or other nsaid nonsteroidal antiinflammatory drug. Regular article analytical and bioanalytical chemistry. Clinical pharmacology and cardiovascular safety of naproxen dominick j. Over the last decade, the exploration of graphene and.
Usually the tens electrode pads are placed on each temporomandibular joint, as well as at the neck below the base of the head. Effects of electrode reversal on the distribution of naproxen in the electrospun cellulose acetate nanofibers zhuangli,1,2 hongliangkang,1 ningche,1,2 zhijingliu,1,2 pingpingli,1,2 weiweili,1 chaozhang,1,2 chuncao,1,2 ruigangliu,1 andyonghuang1,3. Clinical pharmacology and cardiovascular safety of naproxen. Abstract naproxen membrane electrodes based on different plasticizers and the quaternary ammonium salts qass dimethyldidecylammonium bromide, methyltrioctylammonium chloride, or tetraoctylammonium chloride, were prepared. Researcharticle effects of electrode reversal on the distribution of naproxen in the electrospun cellulose acetate nanofibers zhuangli,1,2 hongliangkang,1 ningche,1,2 zhijingliu,1,2 pingpingli,1,2 weiweili,1.
A solid naproxen xylitol dispersion was prepared, which showed a reduction of the. Electrostatic precipitation of submicron particles in a. Therefore, using electrochemical methods by electrode modified with acnps, in addition to improving the surface of electrode for oxidation of drug and reducing the overvoltage, increases the sensitivity, accuracy, and selectivity of electrode. By using the cile as the basal electrode, hemoglobin hb was immobilized on the surface of the cile with nanocaco3 and. This article is published with open access at abstract the voluntary withdrawal of vioxx rofecoxib from the market in 2004, as well as the 2005 and 2014 us. The composite was dropped onto a glassy carbon electrode gce, and the modified gce displays robust electrocatalytic activity towards amp, npx, and tph, with voltammetric signals that are enhanced compared to. Effects of electrode reversal on the distribution of naproxen in the electrospun cellulose. Naproxen sodium is an odorless crystalline powder, white to creamy in color.
Research article effects of electrode reversal on the. Carbon paste electrodes cpes modified with different carbon nanomaterials, namely, glassy carbon powder gce, multiwall carbon nanotubes mwcnts, singlewalled carbon nanotubes. Nanomaterialbased carbon paste electrodes for voltammetric. Naproxen, sold under the brand name aleve among others, is a nonsteroidal antiinflammatory drug nsaid used to treat pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, and fever. The electrode was applied for determination of naproxen in drugs and urine samples.
In this work the use of the bdd electrode to assay selected biocides in water samples contaminated. Electrochemistry and concentration effects on electrode. Oct 24, 2003 read determination of naproxen in pharmaceuticals by differential pulse voltammetry at a platinum electrode, analytica chimica acta on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Get a printable copy pdf file of the complete article 890k, or click on a page image below to browse page by page. The newly developed melt electrostatic precipitator was able to collect isolated naproxen particles in a molten carrier. Properties of naproxen ionselective electrodes springerlink.
Potentiometric determination of ibuprofen, indomethacin. The effects of the electrode polarity on the distribution of drugs in nanofibers can be used to prepare hybrid electrospun fibers of different drug release rates, which may found applications in biomedical. The pharmacokinetics of naproxen, its metabolite o. The electrode exhibits favourable analytical parameters. Using a tens unit can help and knowing where to place the electrode pads is very important. Previous work from this laboratory dealt with the development of mercuryicarboxylate electrodes and their application to solution equilibria, 2125 food analysis, 26 and pharmaceutical analysis 27,28 involving carboxylate bearing compounds. Naproxen napcellulose acetate hybrid nanofibers were prepared by positive and reversed emitting electrodes electrospinning setups. Naproxen s medical uses are related to its mechanism of action as an antiinflammatory compound. Simultaneous voltammetric determination of acetaminophen.
Likewise, npx detection by cv using mwcnts modified electrode was researched montes et al. Naproxen is a propionic acid derivative related to the arylacetic acid group of nonsteroidal antiinflammatory drugs. Reviewing the literature revealed that naproxen oxidation was studied in the different works. This new approach, allows the proposal of a simple and competitive lowcost method to carry out naproxens voltammetric quantification. Side effects of naprelan naproxen sodium, warnings, uses. Preparation and study of a naproxen ionselective electrode article in materials science and engineering c 331. The pharmacokinetics of naproxen, its metabolite odesmethylnaproxen, and their acyl glucuronides in humans. The results were also compared with glassy carbon electrode gc under the. This standard electrode is arbitrarily assigned a potential of 0 volts, and. The morphology and structure of the resultant nanofibers were characterized, and the nap release behaviors were investigated. Effects of electrode reversal on the distribution of. The notable property is high selectivity, low cost, and very long lifetime20 months. The electrode is easily constructed at a relatively low cost with fast response time within 1035 s and can be used for a period of 6 months without any considerable divergence in potentials.
The purpose of this research was to sensor design as soon. Effects of electrode reversal on the distribution of naproxen in the electrospun cellulose acetate nanofibers zhuangli, 1,2 hongliangkang, 1 ningche, 1,2 zhijingliu, 1,2 pingpingli, 1,2 weiweili, 1 chaozhang, 1,2 chuncao, 1,2 ruigangliu, 1 andyonghuang 1,3. Electrochemistry and concentration effects on electrode potentials special mention and thanks goes to dr. The oxidative behavior of diclofenac sodium dcf has been investigated by cyclic voltammetric and differential pulse voltammetric techniques, using a tyrosinemodified carbon paste electrode tcpe.
Electrochemistry and electrocatalysis of hemoglobin in nafion. Naproxen may increase your risk of heart attack or stroke, especially if you use it long term or have heart disease. Timothy friebe for his help in developing this laboratory writeup. The electrochemical measurements performed by cyclic voltammetric cv and. Voltammetric assay of naproxen in pharmaceutical formulations. Naprosyn oral suspension fda prescribing information, side. Oct 28, 2008 naproxen membrane electrodes based on different plasticizers and the quaternary ammonium salts qass dimethyldidecylammonium bromide, methyltrioctylammonium chloride, or tetraoctylammonium chloride, were prepared. The composite was dropped onto a glassy carbon electrode gce, and the modified gce displays robust electrocatalytic activity towards amp, npx, and tph, with voltammetric signals that are enhanced compared to a bare gce.
Naproxens indirect quantification through an adsorption anodic wave was performed at a graphite bar electrode using differential pulse voltammetry. Electrochemical determination of naproxen in the presence. Naproxen is used to treat a variety of inflammatory conditions and symptoms that are due to excessive inflammation, such as pain and fever naproxen has feverreducing, or antipyretic, properties in addition to its antiinflammatory activity. Properties of naproxen ionselective electrodes, open. Electrochemical degradation of naproxen from water by anodic. Effects of electrode reversal on the distribution of naproxen in the electrospun cellulose acetate nanofibers zhuang li, hongliang kang, ning che, zhijing liu, pingping li, weiwei li, chao zhang, chun cao, ruigang liu, yong huang. It was found that nap dispersed in the ca matrix in molecular level, and no aggregation and dimers of nap were found in the resultant. Zno nanoparticles and multiwalled carbon nanotubes. Although it is a hydroxylsubstituted naphthol rather than a simple phenol it has similar cv properties. Potentiometric determination of antiinflammatory agents 89 there are a number of publications on multivariate analysis, including. Previous electroanalytical methods for naproxen determination did report electrode adsorption processes resulted from the electrochemical oxidation of naproxen. Request pdf determination of naproxen in pharmaceuticals by differential pulse voltammetry at a platinum electrode the anodic oxidation of naproxen has been carried out on a platinum electrode.
Research article effects of electrode reversal on the distribution of naproxen in the electrospun cellulose acetate nanofibers zhuangli, 1,2 hongliangkang, 1 ningche, 1,2 zhijingliu, 1,2 pingpingli, 1,2 weiweili, 1. Only select registry of toxic effects of chemical substances rtecs data is presented here. Dysprosium nanowire modified carbon paste electrode for the simultaneous determination of naproxen and paracetamol. The electrode was applied for the determination of naproxen in tablets. The electrochemical oxidation of naproxen and paracetamol was investigated using dysprosium nanowire modified carbon paste electrode dynwcpe by square wave voltammetry as a new rapid, convenient and sensitive method. Electroanalytical investigation on paracetamol on borondoped. The results were also compared with glassy carbon electrode gc under the same conditions. Pdf dysprosium nanowire modified carbon paste electrode for. Effects of electrode reversal on the distribution of naproxen in the electrospun cellulose acetate nanofibers. Naproxen membrane electrodes based on different plasticizers and the quaternary ammonium salts qass dimethyldidecylammonium bromide, methyltrioctylammonium chloride, or tetraoctylammonium. Experimental apparatus the electrode potentials were measured using a hanna 9321 microprocessor ph meter.
The following basic parameters were investigated for the optimal electrode. Snaproxen investigated as a drug, mutagen, primary irritant, and reproductive effector. Naprosyn suspension naproxen is available as a light orangecolored opaque oral suspension containing 125 mg5 ml of naproxen for oral administration. The bdd electrode has been used to assay various antibiotics tetracycline, erythromycin, sulfamethoxazole, antidepressants e. The solution conditions and operating parameters were optimized. An increased incidence of myocardial infarction and stroke was found in clinical trials of a cox2 selective nsaid for the treatment of pain in the first 10 to 14 days after cabg surgery. Naprelan is also used in the relief of mild to moderate pain and the treatment of primary dysmenorrhea. See actual entry in rtecs for complete information. While naproxen is not a form of aspirin, both drugs can effect bleeding times.
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